Can CBD interact with drugs?

It would be advisable to read the substances with which CBD may interact before mixing it with drugs. Because although it’s impossible to overdose on CBD oil, the plant’s essence can affect the way your body processes certain drugs and toxins. Sometimes with dangerous consequences as a result. So below is what you need to know about CBD oil and its possible interaction with medications:

Medicines for metabolism
As you may know, substances such as drugs, toxins and natural supplements like CBD oil need metabolism to be processed by the body. In general, this process consists of two phases. In phase I, a reaction occurs to make the substance polar (water-soluble), if necessary. This happens by oxidation, reduction or hydrolysis. In phase II, the substance is conjugated by acetylation or methylation. This significantly increases the water solubility and polarity of the drug or toxin, for example. This also facilitates the excretion of the substance through the kidneys and bile.

P450 Cell Colour System
One of the body’s systems responsible for processing “foreign substances” is the cytochrome P450 enzyme system. A group of 57 different enzymes (also known as CYP, P450 or CYP450) of which 15 are used to break down (foreign) substances. This includes certain drugs and toxins – in addition to natural ingredients, including CBD and other cannabinoids. In addition to the metabolism of drugs, toxins, natural substances and other foreign substances, these enzymes are also involved in other physiological processes such as the oxidation of fatty acids.

It should be noted that each person reacts differently to a particular dose of a medicine or natural supplement. Because the capacity of P450 enzymes also varies per individual. This means that the rate at which a substance is broken down and excreted affects its concentration in the body. Thus it probably affects the way it affects the body as a result.

Inhibition of P450 enzyme function
In addition, some natural substances are known to inhibit the function of the CYP enzyme as well. Logically, consuming them when taking drugs could increase the levels of certain drugs in the blood – or other substances – that are broken down by this enzyme.

When this is controlled, it can be good. Considering that you may need less of the particular substance to achieve the same result. Although in uncontrolled circumstances, it could be a little more dangerous. As it could accidentally increase the concentration of certain drugs in the blood. increasing the risk of negative or serious side effects as well.

CBD and chemotherapy
As it turns out, Cannabidiol (CBD) is one of the natural substances that inhibit P450 enzymes. Seeing these are responsible for the breakdown of certain drugs in the body; The use of high doses of CBD could affect the concentration of certain substances in the blood.

For example, CBD inhibits P450 enzymes from breaking down the cytostatic drug. This includes most forms of chemotherapy. And considering the fact that curative and lethal doses of chemotherapy are often not far apart. It would be advisable not to use large amounts of CBD oil during chemotherapy.

Other drugs that may interact with CBD are:
– Antiepileptics
– Anticoagulants
– Blockers beta
– Antipsychotics
– Benzodiazepines
– statins
– Refractory
– steroids
– antibiotics

It is recommended that you watch your CBD dosage when using the aforementioned medications. Obviously, it is always a good idea to discuss the use of CBD with your doctor


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